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KMID : 1039920160230010059
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Neonatal Medicine
2016 Volume.23 No. 1 p.59 ~ p.63
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Oral Proton Pump Inhibitor for Treatment of Congenital Chloride Diarrhea
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Jo Hee-Cheol
Yoon Jong-Seo
Jang Joo-Young
Sohn Young-Bae
Lee Jang-Hoon
Cheong Hae-Il
Park Moon-Sung
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Abstract
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Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease, which is characterized by electrolyte absorption defect due to impaired function of the Cl-/HCO3- exchanger in the ileum and the colon. Its main features are profuse watery diarrhea, high fecal chloride concentration, and failure to thrive. Profuse watery diarrhea characterized by a high concentration of chloride in stools results in hypochloremia, hyponatremia, and dehydration with metabolic alkalosis. Early detection and therapeutic intervention can prevent life-threatening symptoms of CCD and growth failure. Recently, several therapies, such as proton pump inhibitors and butyrate, have been suggested for amelioration of diarrhea. Here, we report a case of CCD in a preterm male infant who was successfully treated with an oral proton pump inhibitor.
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KEYWORD
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Congenital chloride diarrhea, Alkalosis, SLC26A3, Proton pump inhibitor, Omeprazole
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